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ABOUT US

Huabo Biopharm (Shanghai) Co., Ltd.

Huabo Biopharm Co., Ltd., (aka ‘Huabo Biopharm’), established in June 2011, is a subsidiary of Shanghai Huaota Pharmaceutical Co., Ltd. At Huabo Biopharm, the R&D team is led by two distinguished experts. As one of the inventors of a blockbuster biologics, Skyrizi, Dr. Xiangyang Zhu has more than 20 years of industry experience in novel biological drugs development. Dr. Yifan Zhan is a senior scientist with more than 30 years research experience in the field of immunology. The team has rich experience in the development of biotherapeutics including monoclonal antibodies, bispecific antibodies, and fusion proteins. Huabo Biopharm was certified as High- and New-Technology Enterprise in 2018 and has undertaken and completed many science and technology projects in collaboration with universities, research institutes, and other research organizations in China and globally. Huaobo Biopharm has applied for over 20 domestic and international invention patents.

Huabo Biopharm focuses on the research and development of new biological drugs in different therapeutic areas including tumors and autoimmune diseases.  Comprehensive R&D platforms have been well established for antibody discovery, cell line development, upstream and downstream process development, protein quality research and structural characterization, antibody function analysis, and formulation development. Currently, there are almost twenty research projects under development, many of them have obtained IND approval for clinical trials. The flagship Project HB0025 has entered phase I trial in both the United States and China as the world’s first bispecific antibody against PD-L1 and VEGF fusion protein for the treatment of solid tumors.


MANAGEMENT TEAM

Dr. Zhu is a well-recognized expert in antibody drug discovery, process development, and manufacture facility construction. Prior to joining Huahai, he worked at Boehringer Ingelheim for more than 8 years in different function areas at multiple locations (Ridgefield, USA; Biberach, Germany; and Shanghai, China). He led and engaged in over 20 global biological research projects including current clinic Phase I-III projects and market products especially the successful development of blockbuster biologics, Skyrizi at BI. Before BI, Dr. Zhu had worked in the field of antibody drug discovery and process development with more than 20 years of industrial experience

 

Dr. Zhu holds a Ph.D. degree in microbiology and immunology from the University of Illinois at Chicago.


Dr. Zhan is the vice president of antibody discovery and mainly responsible for identifying new targets, designing new antibody molecules and developing the RD technical platforms at Huaota. 

Dr. Zhan has long been engaged in research in the field of cellular immunity and has made significant contributions in the fields of immune cell activation/differentiation/survival, cell interaction, production of cytokine and antibody. Dr. Zhan has published more than 100 peer-reviewed papers in top international journals. His research focuses on the participation of immune cells and cytokines in the onset and treatment of tumors, autoimmune diseases, and infectious diseases, and has obtained related patents and products.

Dr. Zhan received his Ph.D. degree in immunology from the University of Melbourne, Australia, and then worked at the Walter and Eliza Hall Institute of Medical Research in Australia.


Dr. Yang is the vice president of clinical development and mainly responsible for clinical development strategy, medical affairs, and clinical operations at Huaota.

Prior to joining Huaota, Dr. Yang led large molecule bioanalytical team of WuXi AppTec and Covance mainly supporting clinical trials of various large molecule drugs as well as biosimilars, participated in hundreds of global clinical trials including phase I, II, III, and IV supporting bioanalytical and pharmacokinetics.

Dr. Yang worked among institutions such as MPI research, IGE Therapeutics, Pharmacia, Genset and University of Arizona etc. for nearly 18 years with increasing responsibilities from research scientist, Sr. scientist, and Chief scientist involving therapeutic protein/antibody development, functional genomics, molecular microbiology, tumor biology and molecular pathology.

Dr. Yang received Bachelor of Medicine (equivalent to MD) from Lanzhou Medical School and obtained his Ph.D. in Microbiology and Immunology from Chinese Academy of Preventive Medicine now Chinese CDC.  

Dr. Yang is also the main contributor for the First Prize of National Science and Technology Award and First Prize of Science and Technology Award by the Ministry of Public Health.


Dr. Chen is the vice president of quality and compliance and mainly responsible for managing the quality and compliance related activities at Huaota.

Dr. Chen has about 15 years of pharmaceutical research and development experience. Prior to joining Huaota, Dr. Chen had served at several positions in different countries with increasing responsibilities in Boehringer Ingelheim and Johnson & Johnson, primarily in the fields of analytics, quality and compliance. 

Dr. Chen holds a bachelor’s degree from Shanghai Medical College of Fudan University, a master’s degree from Shanghai institute of Organic Chemistry, Chinese Academy of Sciences, and a Ph.D. degree from the Pennsylvania State University. 


COMPANY MILESTONES

  • 2021

    Merging of Zhejiang Huahai Biopharmaceuticals Co., Ltd. as a subsidiary of Huaota focusing on manufacturing of phase III clinical trial supplies and commercial products 

    Multiple projects obtained IND approval (HB0025 from FDA, HB0030 from CDE, HB0034 from New Zealand)

  • 2020

    In January, Huaota received Manufacture License of Pharmaceutical Products

    Multiple projects obtained IND approval (HB0017 ,HOT-1030,HB0025, HB002.1M)


  • 2019

    In June, Huaota entered into an agreement with Shanghai Junshi Biosciences Co., Ltd; Junshi acquired the Avastin monoclonal antibody biosimilar (project code "HOT-1010") from Huaota

    In December, Huaota was certified as High –and New-Technology Enterprise


  • 2018

    In November, Huabo Biopharm was certified as High –and New-Technology Enterprise

    In March, Huaota completed the shareholding system reform and renamed “Shanghai Huaota Biopharmaceutical Co., Ltd.”

    In March, Huaota started the first  clinical trial: Phase I study of HB002.1M, a VEGFFR1-Fc for ophthalmic injection


  • 2017

    In September, Huahai Pharmaceutical reached a strategic collaboration  with Korea Eutilex Co., Ltd.

    In June, Huaota received the first IND approval for clinical trial of the  project HB002.1M, a VEGFFR1-Fc for ophthalmic injection

  • 2016

    In August, Huaota’s pilot plant was officially launched.


  • 2013

    In September, Huaota was established

    In May,Huahai Pharmaceutical reached a strategic collaboration with US Oncobiologics Inc.

  • 2011

    In June, Huabo Biopharm was established

COMPANY CULTURE

  • Mission

    Innovation brings the future, Quality makes the brand

  • Vision

    To establish a world class biopharma developing high-quality yet affordable novel biologics to address unmet medical needs globally

  • Core Values

    Innovation, Quality, Perseverance


  • Culture

    Open-mindedness, Collaboration, Integrity, Dedication


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